Wednesday, February 22, 2012

Botox!

I'm going to go way back and tell you all a little bit about botulinum toxins, which are produced by the bacteria Clostridium botulinum.  Botulinum neurotoxins are the most poisonous substances on Earth.  They cause paralysis by targeting a specific protein in the synaptic vesicle and plasma membrane 
of neurons.  These toxins prevent acetylcholine from being released and cause botulism. 


http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001624/


There are seven known serotypes of botulinum neurotoxins, all of which are classified as category A bioterrorism agents! 


http://www.biomedcentral.com/content/pdf/1471-2180-11-232.pdf


In small doses, these toxins can be used to block the release of neurotransmitters that cause pain, muscle spasms and other symptoms associated with diseases like arthritis, asthma, and psoriasis.  Interestingly, the protein that botulinum toxin targets exists in non-nerve cells also, but these cells lack the receptors needed for the toxin to enter and work in the cell.  In recent experiments, botulinum toxin was attached to a molecule that non-nerve cells do have receptors for.  These engineered botulinum toxins block the release of a protein from immune cells linked to inflammation, which is a major problem in many diseases.  This very dangerous toxin could potentially be beneficial to people with chronic inflammatory diseases!  Go figure.  


http://www.sciencedaily.com/releases/2011/11/111130100451.htm

4 comments:

Julia said...

It's really amazing that the most dangerous substance on earth can help people treat their affections.

When I first heard about Botox Toronto for excessive sweating I thought that's just a marketing campaign...but after my brother had it to get rid of excessive sweating I realized this is really working....He tried many treatments but not even one was at least close to what Botox offered.

Katie Hallison said...

It can be a handy tool for medical purposes, indeed. With regards to its use for cosmetic reasons, the licensed professionals are there to make sure the use of Botox is regulated, so the amount used is only enough to improve the aesthetics of the human body.

John Dudley said...

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David Harley said...

Botox is indeed a miraculous drug. Besides treating wrinkles, it can also treat excessive sweating and migraines. But the results of the treatment depend largely on the expertise of the practitioner. It is necessary that the practitioner has got the training from a reputable aesthetic institute such as www.theharleystreet.com which provides hands-on training by professional cosmetic doctors.