Wednesday, January 11, 2012
Stem cell seminar tomorrow (Jan 12th)
LSB 1001 (Rathmann Auditorium)
Hosted by: Tony De Tomaso
A Doreen J. Putrah Cancer Foundation Research Lecture
Speaker: Dr. Leanne Jones, Associate Professor, Salk Institute
Title: "Mechanisms regulating aging of stem cells and the niche"
The Jones lab is using fruit fly Drosophila melanogaster as a model system to establish paradigms for how stem cell behavior is controlled. Adult stem cells can be easily located in the fly intestine and testis, and the stem cells that maintain these tissues are remarkably similar to their mammalian counterparts. Therefore, it is possible to study these cells in the context of their normal environment without destroying the tissue. Being able to study the behavior of stem cells in vivo allows us to begin to ask questions about how the niche can control stem cell self-renewal and survival and how the relationship between stem cells and the niche evolves during development, as a consequence of aging, and during tumor initiation and progression. Importantly, lessons learned from the study of stem cells in fruit flies has already told us much about how stem cell behavior is regulated in more complex tissues in mammals.